Synaptic Plasticity and the Mechanism of Alzheimer's Disease (Research and Perspectives in Alzheimer's Disease)
by Dennis J. Selkoe (Editor), Antoine Triller (Editor)
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A biochemical hypothesis - that Alzheimer's disease (AD) is a progressive cerebral amyloidosis caused by the aggregation of the
amyloid b-protein (Ab) - preceded and enabled the discovery of etiologies. This volume serves as a record focused on bringing together investigators at the forefront of elucidating the structure and function of hippocampal synapses with investigators focused
on understanding how early assemblies of Ab may compromise
some of these synapses.
Synaptic Plasticity and the Mechanism of Alzheimer's Disease (Research and Perspectives in Alzheimer's Disease)
EDITOR
Dennis J. Selkoe, MD, is the Vincent and Stella Coates Professor of Neurologic Diseases at Harvard Medical School and Brigham and Women's Hospital (BWH). He is the co-founder
and co-director of the Center for Neurologic Diseases at BWH and co-founder and co-chair of the Harvard NeuroDiscovery Center. A graduate of Columbia University and the University of Virginia School of Medicine, Dr. Selkoe completed training at the National Institutes of Health (NINDS), followed by a residency in neurology at the Harvard Longwood Neurology Program and then a fellowship in cell biology and neurochemistry in the Department of Neuroscience at Boston Children's Hospital.
Antoine Triller is Director of Research at the Institut National de la Santé de la Recherche Médicale (INSERM). He obtained his MD in 1978, and his DSc in 1985 from the University Pierre and Marie Curie, while being at the Pasteur Institute. He worked initially on synaptic inhibitory neurotransmission with Henri Korn, correlating quantal parameters of release with the ultrastructure of the synapse. In 1985 he could establish that glycine receptors form postsynaptic microdomains. It was then the first ultrastructural visualization of a receptor in the CNS. In 1995 he joined the Department of Biology at the Ecole Normale Supérieure where he settled a group working on the cellular biology of synapses.
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